自身免疫性肝炎
甘露糖
刀豆蛋白A
免疫学
甘露糖受体
脾细胞
炎症
肝炎
生物
医学
免疫系统
巨噬细胞
生物化学
体外
作者
Daisuke Ito,Hiroyasu Ito,Takayasu Ideta,Ayumu Kanbe,Masahito Shimizu
标识
DOI:10.1016/j.cellimm.2022.104517
摘要
A recent study revealed that d-mannose suppressed immunopathology in mouse models of autoimmune diabetes and airway inflammation and increased the proportion of regulatory T cells (Tregs) in mice. We investigated the effect of d-mannose on liver injury in murine autoimmune hepatitis (AIH) models induced by concanavalin A (ConA) and α-galactosylceramide (GalCer). Mouse models of AIH were created by intraperitoneal injection of GalCer or intravenous injection of ConA. Drinking water was supplemented with d-mannose and biochemically and pathologically examined over time. The administration of d-mannose to AIH model mice significantly reduced liver injury and reduced inflammatory cytokine expression. In addition, Tregs among splenocytes and intrahepatic lymphocytes were significantly increased by the administration of d-mannose. These results indicate that treatment with d-mannose reduced the inflammatory response in the liver and suppressed liver damage by increasing Tregs.
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