生物相容性
PLGA公司
脚手架
生物医学工程
材料科学
骨髓炎
植入
万古霉素
药物输送
骨愈合
牙科
医学
外科
金黄色葡萄球菌
纳米技术
纳米颗粒
冶金
细菌
生物
遗传学
作者
Xiaoming Qiu,Songkai Li,Xun Li,Yong Xiao,Shengtang Li,Qiangsheng Fen,Xuewen Kang,Zhen Peng
标识
DOI:10.1016/j.colsurfb.2022.112424
摘要
Antibiotic bone cement filling technology has been widely used in the treatment of infectious bone defects for decades. However, the current treatment requires multiple complicated procedures, which would lead to pain and financial burden for patients. Repairing bone defects and control infection at the same time is the pain spot of orthopaedic area. In this study, we develop a composite scaffold that aiming at effectively repair infectious bone defects simultaneously. Vancomycin hydrochloride(Van) /Poly(lactic-co-glycolic) acid(PLGA) microspheres prepared by double emulsion method were successfully loaded into β-tricalcium phosphate scaffold through electrostatic and physical crosslinking. Full characterization, including mechanical properties, biocompatibility, in vitro release profile and antibacterial properties of the composite scaffolds(CPSFs) were performed. The rabbit osteomyelitis model based on big hole and small hole methods was established. Pharmacodynamics study, including the local bacteriostatic and osteogenic ability were evaluated by X-ray, Micro-CT and histopathology at 4 months after surgery. These findings indicate that a reliable rabbit model of local bone defect infection successfully established by big hole approach. The CPSFs with significant histocompatibility and biocompatibility could sustained release vancomycin for extended duration. It exhibited great application potential in clinical aim at the indication of local infectious bone defects.
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