免疫疗法
免疫系统
免疫学
自身免疫
医学
抗原
癌症免疫疗法
抗原呈递
细胞毒性T细胞
T细胞
生物
体外
生物化学
作者
Ja Hyun Koo,Gil-Ran Kim,Kyung-Ho Nam,Je-Min Choi
标识
DOI:10.1016/j.molmed.2022.03.010
摘要
With the advent of cancer immunotherapy, immunomodulation has emerged as an important strategy for the treatment of various diseases. We review recent advances in clinical trials of cell-penetrating peptide (CPP) applications for immunotherapy and also discuss their challenges and opportunities for preclinical studies in various immune diseases. CPP conjugation to antigenic peptides or proteins can enable efficient antigen uptake and cross-presentation by antigen-presenting cells (APCs), which induce both humoral and cytotoxic responses. In addition, CPP-coupled immune modulators can enhance antitumor immunity or anti-inflammatory effects to regulate allergies and autoimmunity. Given their huge advantages in overcoming delivery barriers, CPP-based strategies for immunomodulation could extend drug optimization and advance immunotherapy in various human diseases.
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