毛细管电色谱
化学
金属有机骨架
色谱法
毛细管作用
毛细管电泳
环糊精
电色谱法
手性柱色谱法
介孔材料
吸附
高效液相色谱法
有机化学
催化作用
复合材料
材料科学
作者
Chen Wang,Dongyang Zhu,Jian Zhang,Yingxiang Du
标识
DOI:10.1016/j.jpba.2022.114777
摘要
Metal organic frameworks (MOFs), as a novel separation mediums, have in recent years attracted wide consideration in capillary electrochromatography (CEC). However, the instability of frameworks limited the application of the MOF-based chiral separation capillary. Herein, Iron-based γ-cyclodextrin metal-organic framework (Fe-CD-MOF) with mesoporous was developed as the chiral stationary phase in open tubular capillary electrochromatography column (OT-CEC) for the stereoisomer separation of fourteen chiral drugs and one chiral alcohol. The capillary column with MOF coating exhibited the best performance (resolution value: 17.07) for anisodamine in any MOF-based capillary column that has never been reported. Moreover, the effect of pH, buffer concentration, and methanol content has been investigated. The novel coated capillary was also applied for the quantitative analysis of a real sample. The Fe-CD-MOF coated capillary showed outstanding repeatability and stability, with the satisfactory relative standard deviations (RSDs) for intra-day, inter-day, and column-to-column. Finally, the enantioseparation mechanism of the Fe-CD-MOF coated capillary was evaluated by adsorption kinetic experiments. In summary, this work indicated the novel and renewable Fe-CD-MOF was a potential chiral stationary phase in CEC chiral separation.
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