卡哈尔体
snRNP公司
核仁
剪接体
细胞生物学
小核核糖核蛋白
小核RNA
核糖核蛋白
核运输
细胞质
细胞核
生物
化学
RNA剪接
核糖核酸
遗传学
基因
非编码RNA
作者
Debra J. Shaw,Paul Eggleton,Philip J. Young
标识
DOI:10.1016/j.bbamcr.2008.07.025
摘要
The spliceosome is the RNP complex than catalyses the removal of introns from the Uridine-rich small nuclear ribonucleoproteins (U snRNPs) that make up the main components of this complex. The production of these RNPs is an intricate process, involving several key stages. These include: 1) the transcription of the U snRNAs; 2) their nuclear export; 3) the cytoplasmic assembly of the U snRNP; 4) their nuclear import; 5) their processing within Cajal bodies and the nucleolus; and 6) their storage in interchromatin granule clusters (IGCs). This review focuses on each of these stages, discussing the key complexes involved as well as the trafficking and targeting mechanisms involved.
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