trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion

TXNIP公司 硫氧还蛋白相互作用蛋白 硫氧还蛋白 白藜芦醇 抗氧化剂 化学 下调和上调 硫氧还蛋白还原酶 药理学 癌症研究 生物化学 生物 氧化应激 基因
作者
Valérie Nivet-Antoine,Charles‐Henry Cottart,Hervé Lemarechal,Michel Vamy,Isabelle Margaill,Jean-Louis Beaudeux,Dominique Bonnefont‐Rousselot,Didier Borderie
出处
期刊:Biochimie [Elsevier BV]
卷期号:92 (12): 1766-1771 被引量:34
标识
DOI:10.1016/j.biochi.2010.07.018
摘要

Txnip (thioredoxin-interacting protein) is a protein with multifunctional roles in cellular responses and stress-related diseases. Txnip is involved in intracellular redox regulation and has been recently described as a possible link between redox state and metabolism. trans-Resveratrol (T-res) is a natural phytoalexin with antiproliferative, antiapoptotic and antioxidative effects. However, to date there have been no reports of the implication of Txnip in a model of liver acute stress such as ischemia-reperfusion (I/R) and no work has looked for a T-res effect on Txnip. Here we studied the effects of a post-ischemic treatment of T-res on the liver thioredoxin (Trx)/Txnip system and investigated whether the T-res effects were dependent on NO production. In this work, liver I/R induced hepatic Txnip expression and T-res inhibited I/R Txnip expression. This decrease in Txnip expression by T-res was associated with an increase in liver Trx redox activity and a decrease in hepatic I/R-induced Trx-1 expression with no effect on Trx-2, on plasma Trx redox activity or on liver and plasma Trx reductase activity, independently of NO production. In conclusion, these results show that in our model, not only did T-res protect Trx redox activity by diminishing the Txnip protein expression; it also reduced secretion of Trx1. This is the first report of a major implication of the Trx1/Txnip system in hepatic I/R injuries. It also affirms the importance of the antioxidant effect of T-res on the Trx1/Txnip system.
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