星形胶质细胞
神经科学
糖皮质激素受体
糖皮质激素
树突棘
味觉厌恶
刺激
受体
心理学
生物
内分泌学
中枢神经系统
医学
内科学
海马结构
品味
作者
Magdalena Tertil,Urszula Skupio,Justyna Barut,Valentyna Dubovyk,Agnieszka Wawrzczak-Bargieła,Zbigniew Sołtys,Sławomir Gołda,Lucja Kudla,Lucja Wiktorowska,Klaudia Szklarczyk,Michał Korostyński,Ryszard Przewłocki,Michał Ślęzak
标识
DOI:10.1038/s41398-018-0300-x
摘要
Stress elicits the release of glucocorticoids (GCs) that regulate energy metabolism and play a role in emotional memory. Astrocytes express glucocorticoid receptors (GR), but their contribution to cognitive effects of GC's action in the brain is unknown. To address this question, we studied how astrocyte-specific elimination of GR affects animal behavior known to be regulated by stress. Mice with astrocyte-specific ablation of GR presented impaired aversive memory expression in two different paradigms of Pavlovian learning: contextual fear conditioning and conditioned place aversion. These mice also displayed compromised regulation of genes encoding key elements of the glucose metabolism pathway upon GR stimulation. In particular, we identified that the glial, but not the neuronal isoform of a crucial stress-response molecule, Sgk1, undergoes GR-dependent regulation in vivo and demonstrated the involvement of SGK1 in regulation of glucose uptake in astrocytes. Together, our results reveal astrocytes as a central element in GC-dependent formation of aversive memory and suggest their relevance for stress-induced alteration of brain glucose metabolism. Consequently, astrocytes should be considered as a cellular target of therapies of stress-induced brain diseases.
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