磁刺激
神经科学
精神分裂症(面向对象编程)
前额叶皮质
心理学
神经可塑性
背外侧前额叶皮质
脑刺激
经颅直流电刺激
神经影像学
认知
刺激
精神科
作者
Urvakhsh Meherwan Mehta,Shalini S Naik,Milind Vijay Thanki,Jagadisha Thirthalli
标识
DOI:10.1007/s11920-019-1076-2
摘要
This current review summarizes the investigational and therapeutic applications of transcranial magnetic stimulation (TMS) in schizophrenia.Fairly consistent findings of an impaired cortical excitation-inhibition balance, cortical plasticity, and motor resonance have been reported in schizophrenia. Cortical connectivity impairments have also been demonstrated in motor and prefrontal brain regions. In terms of treatment, the best support is for 1-Hz TMS to the left temporoparietal cortex for the short-term treatment of persistent auditory hallucinations. High-frequency TMS to the left prefrontal cortex improves negative and cognitive symptoms, but with inconsistent and small effects. TMS combined with diverse brain mapping techniques and clinical evaluation can unravel critical brain-behavior relationships relevant to schizophrenia. These provide critical support to the conceptualization of schizophrenia as a connectopathy with anomalous cortical plasticity. Adaptive modulation of these aberrant brain networks in a neuroscience-informed manner drives short-term therapeutic gains in difficult-to-treat symptoms of schizophrenia.
科研通智能强力驱动
Strongly Powered by AbleSci AI