材料科学
光敏剂
光动力疗法
免疫疗法
介孔二氧化硅
癌症免疫疗法
免疫佐剂
卵清蛋白
介孔材料
生物相容性
癌症研究
抗原
免疫系统
光子上转换
纳米技术
化学
免疫学
医学
光化学
催化作用
生物化学
兴奋剂
有机化学
冶金
光电子学
作者
Binbin Ding,Shuai Shao,Yu Chang,Bo Teng,Meifang Wang,Ziyong Cheng,Ka‐Leung Wong,Ping’an Ma,Jun Lin
标识
DOI:10.1002/adma.201802479
摘要
Reported immunoadjuvants still have many limitations, such as inferior cellular uptake capacity and biocompatibility, overly large particle sizes, single function, and unsatisfactory therapeutic efficacy. Here, large-pore mesoporous-silica-coated upconversion nanoparticles (UCMSs) with a size of less than 100 nm are successfully prepared by a typical silica sol-gel reaction using mesitylene as a pore-swelling agent and are applied as a novel immunoadjuvant. The obtained UCMSs not only show significantly higher loadings for the photosensitizers merocyanine 540 (MC540), model proteins (chicken ovalbumin (OVA)), and tumor antigens (tumor cell fragment (TF)), but also are successfully employed for highly efficient in vivo vaccine delivery. The prepared UCMSs-MC540-OVA under 980 nm near-infrared irradiation shows the best synergistic immunopotentiation action, verified by the strongest Th1 and Th2 immune responses and the highest frequency of CD4+ , CD8+ , and effector-memory T cells. Additionally, nanovaccines UCMSs-MC540-TF can more effectively inhibit tumor growth and increase the survival of colon cancer (CT26)-tumor-bearing BALB/c mice compared with either photodynamic therapy or immunological therapy alone, suggesting the enhanced immunotherapy efficacy and clinical potential of UCMSs as immunoadjuvants for cancer immunotherapy.
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