Based on the theory of gas-liquid flow and the primary equations of single dimensional fluid,the pressure drop calculating equation of two-phase flow about separating flow pattern and uniform flow model were deduced.The calculation instances were given in a horizontal pipeline,and the conclusion is drawn that the relationship between gas-content and pipeline pressure drop has little effect on pressure drop in three-phase-flow pipeline.It shows that the resistance of fluid flow is not raised due to gas increase into pipeline.