Synthesis of 6-Aminopenicilanic Acid Derivates with EDTA and DTPA

The new two complexes,EDTA-6-APA and DTPA-6-APA,were respectively synthesized by reaction of EDTA dianhydride and DTPA dianhydride with 6-aminopenicilanic acid(6-APA).The compositions and structures of the complexes were characterized by UV,IR,1H NMR and elemental analysis.The effects of reactant proportion,reaction temperature and reacton time on the yield were investigated.The optimized parameters for the synthesis were as follows:the molar ratio of dianhydride to 6-APA was 1∶2,and reaction temperature was 25℃ with reaction time of 7h.The yields of the products were all above 70% under the conditions.