小胶质细胞
大脑发育
生物
免疫系统
转录组
染色质
神经科学
转录因子
中枢神经系统
基因表达
基因
神经炎症
炎症
遗传学
免疫学
作者
Orit Matcovitch-Natan,Deborah R. Winter,Amir Giladi,Stephanie Vargas Aguilar,Amit Spinrad,Sandrine Sarrazin,Hila Ben-Yehuda,Eyal David,Fabiola Zelada González,Pierre Perrin,Hadas Keren‐Shaul,Meital Gury,David Lara-Astaiso,Christoph A. Thaiss,Michal Cohen,Keren Bahar Halpern,Kuti Baruch,Aleksandra Deczkowska,Erika Lorenzo-Vivas,Shalev Itzkovitz,Eran Elinav,Michael H. Sieweke,Michal Schwartz
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-08-19
卷期号:353 (6301)
被引量:870
标识
DOI:10.1126/science.aad8670
摘要
Microglia, the resident myeloid cells of the central nervous system, play important roles in life-long brain maintenance and in pathology. Despite their importance, their regulatory dynamics during brain development have not been fully elucidated. Using genome-wide chromatin and expression profiling coupled with single-cell transcriptomic analysis throughout development, we found that microglia undergo three temporal stages of development in synchrony with the brain--early, pre-, and adult microglia--which are under distinct regulatory circuits. Knockout of the gene encoding the adult microglia transcription factor MAFB and environmental perturbations, such as those affecting the microbiome or prenatal immune activation, led to disruption of developmental genes and immune response pathways. Together, our work identifies a stepwise microglia developmental program integrating immune response pathways that may be associated with several neurodevelopmental disorders.
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