Effect of clopidogrel on lipid lowering of atorvastatin in coronary artery disease

Objective To investigate the effect of clopidogrel on lipid lowering of atorvastatin in coronary artery disease.Methods One hundred and twenty-six patients with coronary artery disease received atorvastatin 10 mg/d and 20 mg/d randomly.Those undergoing successful percutaneous coronary intervention received clopidogrel and separated into two groups,group A(43 patients receiving atorvastatin 10 mg/d plus clopidogrel) and group B(29 patients receiving atorvastatin 20 mg/d plus clopidogrel).Those with stable angina pectoris without undergoing percutaneous coronary intervention did not receive clopidogrel and divided into two groups,group C(37 patients receiving alone atorvastatin 10 mg/d) and group D(17 patients receiving atorvastatin 20 mg/d).The serum levels of plasma lipid were determined with biochemistry assay in 24 hours after admission and 1 month after clopidogrel therapy.The difference of plasma lipid was compared between group A and group C,group B and group D.Results There was no statistic difference in the changes of blood lipid,including TC,TG,LDL-C,HDL-C,ApoA,ApoB and Lpa between group A and C,group B and D in 1 month after treatment(P0.05).Conclusion The effect of clopidogrel therapy on the extent of lipid lowering of atorvastatin is not evident in 1 month after treatment.