In order to study the dyeing mechanism of mixed disperse dyes on terylene fabric in supercritical carbon dioxide, a flow-type dyeing apparatus was used to dye terylene fabric in supercritical CO2 with mixed disperse dyes including disperse blue 366 and disperse red 343 at 70~130℃ and 16~24 MPa with 15~100 minutes. The influences of dyeing conditions on the dye uptake were investigated, and the interaction relations between the two dyes during the mixed dyeing process were exposed by comparing the dyeing using the mixed disperse dyes with the dyeing using separately the two dyes composing the mixed dyes. Selectivity and competition between the two composing dyes exist during the dyeing process with mixed dyes. The results indicate that, during the dyeing with mixed dyes, the uptake of the each single dye and the total uptake of the mixed dyes increase with the increase of temperature, pressure and dyeing time. The total uptake of the mixed dyes is more than the uptake of any single dye in the dyeing process with this single dye only (146.8% of single disperse red process and 131.7% of single disperse blue process), and the uptake of disperse blue 366 or disperse red 343 in mixed dyeing process is lower than their uptake in the dyeing process with single disperse dye (average 56.3% of single disperse red process and 81.0% of single disperse blue process). The obtained fastness properties can meet the first-class requirements of the national standard.