Objective To evaluate the curative effect of acupuncture on diarrheogenic irritable bowel syndrome. Method The patients with diarrheogenic irritable bowel syndrome (n=54) were randomly divided into the treatment group and control group (each n=27). The treatment group was treated with acupuncture in the acupoint of BL18, BL20, BL23 and BL25 for 24 times. The control group was given pinaverium bromidel orally for 8 weeks. Result The integrals of diarrhea, abdominal pain, spiritual and mental problems were decreased more significantly in the treatment group than those in the control group. The effective rates of above symptoms were 88.5 %, 91.7 % and 80.0 % respectively. Conclusion Acupuncture has a definite effect on diarrheogenic irritable bowel syndrome.