The Antitumor Effect of Linomide in Treatment of Transplanted Human Squamous Cell Carcinoma of Tongue in Nude Mice

Objective To investigate the antitumor effect of linomide in treatment of transplanted human squamous cell carcinoma of tongue in BALB/C(nu/nu) nude mice.Methods An animal model was established by inoculating the human squamous cell carcinoma cell line Tca 8113 into the BALB/C(nu/nu) nude mice.The mice were randomly divided into three groups and received linomide therapy, the antitumor effect of linomide was observed.Results It showed that subcutaneous tumor growth was significantly inhibited in mice treated with linomide compared with that in controls (P0.01). The tumor volume and weight in nude mice received 100mg/(kg·d) linomide therapy decreased compared with that in nude mice treated with 50mg/(kg·d) linomide (P0.01). And the nude mice treated with linomide survived longer compared with controls (P 0.01). The nude mice treated with 100mg/(kg·d) linomide survived longer compared with the nude mice received 50mg/(kg·d) linomide therapy (P0.01). Conclusion It indicated that linomide effectively inhibited the growth of human squamous carcinoma of tongue Tca8113 in nude mice in a dose-dependent manner.