氯喹
生物
多核苷酸
DNA
生物化学
分子生物学
疟疾
免疫学
作者
Frank Kwakye-Berko,Steven R. Meshnick
标识
DOI:10.1016/0166-6851(90)90066-u
摘要
Chloroquine is a critically important antimalarial drug and a well known intercalator into DNA. We now show that chloroquine binds more avidly to poly(dG-dC)·poly(dG-dC) than to other synthetic polynucleotides and that this binding inhibits both salt- and cobalt-induced transitions to Z-DNA. These data are consistent with the possibility that chloroquine's toxicity to malarial parasites is mediated by its effect on DNA.
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