离子通道
化学
细胞生物学
钙
瞬时受体电位通道
运输机
电压依赖性钙通道
受体
效应器
淋巴细胞
生物物理学
生物
生物化学
免疫学
基因
有机化学
作者
Stefan Feske,Edward Y. Skolnik,Murali Prakriya
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2012-06-15
卷期号:12 (7): 532-547
被引量:356
摘要
Lymphocyte function is regulated by a network of ion channels and transporters in the plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations of diverse cations, such as calcium, magnesium and zinc ions, which function as second messengers to regulate crucial lymphocyte effector functions, including cytokine production, differentiation and cytotoxicity. The repertoire of ion-conducting proteins includes calcium release-activated calcium (CRAC) channels, P2X receptors, transient receptor potential (TRP) channels, potassium channels, chloride channels and magnesium and zinc transporters. This Review discusses the roles of ion conduction pathways in lymphocyte function and immunity.
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