胚泡
体外
胚胎
生物
男科
体外受精
胚胎培养
人类受精
后代
细胞生物学
胚胎发生
体内
生物技术
遗传学
怀孕
医学
作者
Demetrios Rizos,Maria Grazia Clemente,Pablo Bermejo-Alvarez,José de la Fuente,Patrick Lonergan,Alfonso Gutiérrez-Adán
标识
DOI:10.1111/j.1439-0531.2008.01230.x
摘要
Despite major efforts directed at improving the yield of blastocysts from immature oocytes in vitro, the quality of such blastocysts continually lags behind that of blastocysts produced in vivo. These differences are manifested at the level of morphology, metabolism, gene expression and cryotolerance, and may have a knock-on effect further along the developmental axis. Evidence suggesting that in vitro culture conditions, while capable of producing blastocysts in relatively high numbers, are far from optimal with deficiencies being manifested in terms of abnormally large offspring. It is clear nowadays that modification of the post-fertilization culture environment in vitro can improve blastocyst quality to some extent.
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