Total Synthesis and Structural Reassignment of the γ‐Lactone Polyketide from Diaporthe sp. SXZ‐19

Abstract The first stereoselective total synthesis of the proposed structure of the γ‐lactone from Diaporthe sp. SXZ‐19 was achieved by utilizing a convergent pathway. The four stereogenic centers were formed by employing Brown's asymmetric alkoxyallylboration reaction, and a cross‐metathesis reaction was used to construct the trans double bond of the γ‐lactone side chain. This synthesis led to a revision of proposed structural assignment of the natural product.