Very Important Histopathological Factors in Patients with Resected Non-Small Cell Lung Cancer: Necrosis and Perineural Invasion

Perineural invasion and the presence of necrosis independently indicated a dismal prognosis and their prognostic power is comparable to those of the TNM classification. These factors could be candidates for better survival stratification and the indicators of the need for adjuvant therapy in early stage lung cancer patients.