高强度聚焦超声
超声波
医学
止血
放射科
生物医学工程
超声成像
强度(物理)
可视化
计算机科学
外科
人工智能
光学
物理
作者
Shahram Vaezy,Xiaotian Shi,Roy W. Martin,Emil Chi,P Nelson,Michael R. Bailey,Lawrence A. Crum
标识
DOI:10.1016/s0301-5629(00)00279-9
摘要
High-intensity focused ultrasound (HIFU) and conventional B-mode ultrasound (US) imaging were synchronized to develop a system for real-time visualization of HIFU treatment. The system was tested in vivo in pig liver. The HIFU application resulted in the appearance of a hyperechoic spot at the focus that faded gradually after cessation of HIFU exposure. The duration of HIFU exposure needed for a hyperechoic spot to appear, was inversely related to the HIFU intensity. The threshold intensity required to produce a hyperechoic spot in liver in < 1 s was 970 W/cm(2), in situ. At this HIFU dose, no immediate cellular damage was observed, providing a potential for pretreatment targeting. The real-time visualization method was used in hemostasis of actively bleeding internal pelvic vessels, allowing targeting and monitoring of successful treatment. Real-time US imaging may provide a useful tool for image-guided HIFU therapy.
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