自愈水凝胶
生物相容性材料
胶囊
血管生成
植入
抵抗
生物医学工程
纳米技术
化学
材料科学
生物物理学
高分子化学
外科
医学
癌症研究
生物
图层(电子)
植物
作者
Lei Zhang,Zhiqiang Cao,Tao Bai,Louisa R. Carr,Jean Rene Ella-Menye,Colleen Irvin,Buddy D. Ratner,Shaoyi Jiang
摘要
The performance of implantable biomedical devices is impeded by the foreign-body reaction, which results in formation of a dense collagenous capsule that blocks mass transport and/or electric communication between the implant and the body. No known materials or coatings can completely prevent capsule formation. Here we demonstrate that ultra-low-fouling zwitterionic hydrogels can resist the formation of a capsule for at least 3 months after subcutaneous implantation in mice. Zwitterionic hydrogels also promote angiogenesis in surrounding tissue, perhaps owing to the presence of macrophages exhibiting phenotypes associated with anti-inflammatory, pro-healing functions. Thus, zwitterionic hydrogels may be useful in a broad range of applications, including generation of biocompatible implantable medical devices and tissue scaffolds.
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