尼可地尔
医学
心脏病学
射血分数
内科学
心绞痛
安慰剂
冠状动脉疾病
稳定型心绞痛
生活质量(医疗保健)
心力衰竭
心肌梗塞
病理
护理部
替代医学
作者
Ryabikhin Ryabikhin,М Е Можейко,Y.А. Krasilnikova Krasilnikova
出处
期刊:Kardiologiya
[APO Society of Specialists in Heart Failure]
日期:2016-12-02
卷期号:11_2016: 12-17
标识
DOI:10.18565/cardio.2016.11.12-17
摘要
To study the effect of nicorandil on the elasticity of the great vessels, cardiac functional parameters and quality of life in patients with coronary heart disease (CHD).In a double-blind, randomized, placebo-controlled trial of nicorandil was attended by 154 patients with stable angina III functional class (FC), divided into 2 comparable age and sex group. Study duration was 12 months.In the group treated with nicorandil compared with placebo, the number of angina attacks and nitrate intake of short-significantly reduced, improved elastic properties of large arteries, improved quality of life. In a cohort of patients with CHD and left ventricular ejection fraction less than 45% nikorandil addition to standard therapy has improved the systolic function of the heart and reduce left ventricular remodeling.The use of nicorandil in addition to standard therapy can not only improve the quality of life in patients with coronary artery disease, but also a positive impact on the state of elasticity of blood vessels and morpho-functional parameters of the heart.
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