苯硼酸
逐层
胰岛素释放
葡萄糖氧化酶
材料科学
聚合物
纳米技术
过氧化氢
药物输送
图层(电子)
硼酸
化学工程
电催化剂
涂层
组合化学
化学
高分子化学
生物传感器
电化学
有机化学
电极
复合材料
医学
内分泌学
物理化学
1型糖尿病
工程类
糖尿病
催化作用
作者
Baozhen Wang,Kentaro Yoshida,Katsuhiko Sato,Jun Ichi Anzai
出处
期刊:Polymers
[MDPI AG]
日期:2017-05-31
卷期号:9 (12): 202-202
被引量:22
摘要
Recent progress in the development of phenylboronic acid (PBA)-functionalized layer-by-layer (LbL) assemblies and their biomedical applications was reviewed. Stimuli-sensitive LbL films and microcapsules that exhibit permeability changes or decompose in response to sugars and hydrogen peroxide (H2O2) have been developed using PBA-bearing polymers. The responses of PBA-modified LbL assemblies arise from the competitive binding of sugars to PBA in the films or oxidative decomposition of PBA by H2O2. Electrochemical glucose sensors have been fabricated by coating the surfaces of electrodes by PBA-modified LbL films, while colorimetric and fluorescence sensors can be prepared by modifying LbL films with boronic acid-modified dyes. In addition, PBA-modified LbL films and microcapsules have successfully been used in the construction of drug delivery systems (DDS). Among them, much effort has been devoted to the glucose-triggered insulin delivery systems, which are constructed by encapsulating insulin in PBA-modified LbL films and microcapsules. Insulin is released from the PBA-modified LbL assemblies upon the addition of glucose resulting from changes in the permeability of the films or decomposition of the film entity. Research into insulin DDS is currently focused on the development of high-performance devices that release insulin in response to diabetic levels of glucose (>10 mM) but remain stable at normal levels (~5 mM) under physiological conditions.
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