A series of some novel benzothiazole derivatives were synthesized from the 2-(4-aminophenyl) benzothiazol-5-ol, which was synthesized by the Jacobson method using Lawesson’s reagent. Benzylidene derivatives (P201-P205) were synthesized by catalyzed condensation and acylation method,named as 2-(4-((4 hydroxybenzylidene)amino) phenyl) benzothiazole-5-ol (P201), 2-(4-((4- methoxybenzylidene) amino)phenyl)benzothiazole-5ol(P202),2-(4-((4-chlorobenzylidene) amino)phenyl)benzothiazole-5-ol(P203), (4-((furan-2-ylmethylene) amino)phenyl)benzothiazole-5-ol(P204), Dimethyl(4(5hydroxy benzothiazol2yl)phenyl)carbonimidodithioate(P205)The structures of the compounds were confirmed by NMR and IR spectral data.