细胞生物学
表皮(动物学)
MAPK/ERK通路
角质形成细胞
下调和上调
表皮生长因子受体
化学
钙
信号转导
受体
生物
生物化学
体外
解剖
基因
有机化学
作者
Shuang Gao,Yu Chen,Jungang Zhao,Rongrong Jing,Keke Guo,Lusheng Wang,Xuenan Li,Chengliang Li,Zhenlin Hu,Na Xu
标识
DOI:10.1016/j.ijbiomac.2021.07.002
摘要
The integrity of the epidermal barrier and the maintenance of barrier homeostasis depend on the dynamic balance between the proliferation and differentiation of keratinocytes. Calcium (Ca2+) plays a crucial role in maintaining a balance of these two processes as well as in the formation of an epidermal permeability barrier. In this study, we showed that topical application of oat β-glucan (OG) could ameliorate epidermal hyperplasia and accelerate the recovery of the epidermal barrier by promoting epidermal differentiation. Mechanistic studies revealed a positive interaction between OG and the dectin-1 receptor, and this interaction could lead to an upregulated expression of the calcium-sensing receptor (CaSR) via activation of the downstream ERK and p38 pathways. This consequently increased the sensitivity of keratinocytes to extracellular Ca2+ under the condition of calcium loss following the disruption of the epidermal barrier, resulting in the maintenance of normal keratinocyte differentiation in the epidermis, and ultimately promoting the recovery of the epidermal barrier. These findings clearly demonstrated the healing effect of OG on a physically damaged epidermal barrier. Thus, OG could be considered a valuable component in the development of skin repair agents.
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