Uncatalyzed Synthesis of Unsymmetrical Indole-substituted MethaneDerivatives via One-pot Multicomponent Reactions under Solvent-freeConditions

Abstract: For the first time, one-pot multicomponent reactions containing indole, aromatic aldehydes, and dimedone have been achieved in the absence of a catalyst under solvent-free conditions. A class of unsymmetrical indole-substituted methane derivatives and symmetrical diindolylmethanes has been synthesized through this green organic synthetic method. Based on experimental results, a reasonable mechanism for this condensation is emphasized here.