卡铂
顺铂
肺癌
CD44细胞
癌症研究
细胞
细胞生长
癌细胞
细胞凋亡
化学
癌症
化疗
医学
病理
内科学
生物化学
作者
Ting Liu,Xin Huang,Lingyun Zhao,Zhongqing Xiao,Zengbei Li,Xin Yi,Shanshan Yang,Di Guo,Wenda Zhao,Yang Mi,Hongyun Liu
出处
期刊:ChemistryOpen
[Wiley]
日期:2021-08-06
卷期号:10 (9): 882-888
被引量:2
标识
DOI:10.1002/open.202100070
摘要
Lung cancer is the leading cause of cancer deaths worldwide and most cancer patients receiving conventional chemotherapy suffer from severe side effects due to the non-selective effects of chemotherapeutic drugs on normal cells. Targeted nanomaterials can obtain excellent accumulation at the tumor site through their active or passive targeting mechanisms, thereby reducing the toxicity of the drugs in various ways. In this study, hyaluronic acid (HA) which could specifically bind to CD44 on the surface of tumor cells, was used to modify amine-caged platinum nanoclusters (Pt NCs-NH2 ) to obtain targeting HA-Pt NCs-NH2 . Based on the differential expression of CD44 on the surface of three lung cells (non-small cell lung cancer cell H1299, small cell lung cancer cell H446, and embryonic lung fibroblast HFL1), HA-Pt NCs-NH2 can differentially enter the three cells and achieve their targeting of non-small cell lung cancer cell (NSCLC) cells. Pt NCs significantly inhibited the proliferation, migration and invasion of NSCLC cells and induced their apoptosis in comparison of classical cisplatin and carboplatin, showing a bright future in early diagnosis and treatment of NSCLC.
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