TRPV公司
瞬时受体电位通道
破骨细胞
成骨细胞
TRPV1型
骨重建
医学
TRPV4型
人口
化学
骨质疏松症
细胞生物学
神经科学
内科学
内分泌学
生物
受体
生物化学
环境卫生
体外
作者
Na Liu,Weiwei Lu,Xiaolin Dai,Xiaowen Qu,Chong-tao Zhu
标识
DOI:10.1007/s11033-021-06794-z
摘要
As the world's population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca2+ is not only an important component of bones but also plays a key role in osteoporosis treatment. Transient receptor potential vanilloid (TRPV) channels are one of the TRP channel families that is widely distributed in various organs, playing an important role in the physiological regulation of the human body. Bone formation and bone absorption may require Ca2+ transport via TRPV channels. It has been proven that the TRPV subtypes 1, 2, 4, 5, 6 (TRPV1, TRPV2, TRPV4, TRPV5, TRPV6) may affect bone metabolism balance through selective regulation of Ca2+. They significantly regulate osteoblast/osteoclast proliferation, differentiation and function. The purpose of this review is to explore the mechanisms of TRPV channels involved in regulation of the differentiation of osteoblasts and osteoclasts, as well as to discuss the latest developments in current researches, which may provide new clues and directions for an in-depth study of osteoporosis and other related bone metabolic diseases.
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