ctc-[Pt(NH3)2(cinnamate)(valproate)Cl2] is a highly potent and low-toxic triple action anticancer prodrug

The Cin-Pt( iv )-Val prodrug exerts more effective anti-tumor activities in vitro and in vivo than cisplatin by a synergistic mechanism involving DNA damage and inhibition of HDAC and MMP-2 and 9 activities.