内皮干细胞
内皮
医学
细胞粘附分子
内皮功能障碍
血小板
细胞凋亡
细胞生物学
病理
内科学
免疫学
化学
生物
体外
生物化学
作者
Robert Szulcek,Chris Happé,Nina Rol,Ruud D. Fontijn,Chris Dickhoff,Koen J. Hartemink,Katrien Grünberg,Ly Tu,Wim Timens,George Nossent,Marinus A. Paul,Thomas A. Leyen,Anton J.G. Horrevoets,Frances S. de Man,Christophe Guignabert,Paul B. Yu,Anton Vonk Noordegraaf,Geerten P. van Nieuw Amerongen,Harm Jan Bogaard
标识
DOI:10.1164/rccm.201506-1231oc
摘要
Delayed shear adaptation, which promotes shear-induced endothelial injury, is a newly identified dysfunction specific to the microvascular endothelium in PAH. The shear response is normalized on stabilization of PECAM-1, which reverses intimal remodeling in vivo.
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