Schiff bases exhibited various pharmacological and biological activities such as antibacterial, cytotoxic effects, antifungal, and antimalarial. Schiff bases were used for designing organic compounds, metal complexes, or nanoparticles. Also, Schiff bases were applied in various fields as corrosion inhibitors, catalysts, and optical properties. Therefore, this review article focused on some synthesis, reactions, applications, and biological activities of Schiff bases especially Schiff bases-heterocyclic moiety conjugates in the ten last years.