Facile and single-step entrapment of chloramphenicol in ZIF-8 and evaluation of its performance in killing infectious bacteria with high loading content and controlled release of the drug

CLN@ZIF-8 was prepared by trapping chloramphenicol during ZIF-8 synthesis with high DLC and DLE. It showed H 2 O 2 -sensitive controlled release with higher drug release under the simulated infectious conditions and short-time antibacterial activity.