神经调节
神经科学
药物输送
生物相容性材料
微气泡
医学
聚焦超声
经颅多普勒
血脑屏障
超声波
纳米技术
生物医学工程
中枢神经系统
心理学
材料科学
内科学
放射科
作者
Raag D. Airan,Randall A. Meyer,Nicholas Ellens,Kelly R. Rhodes,Keyvan Farahani,Martin G. Pomper,Shilpa D. Kadam,Jordan J. Green
出处
期刊:Nano Letters
[American Chemical Society]
日期:2017-01-23
卷期号:17 (2): 652-659
被引量:134
标识
DOI:10.1021/acs.nanolett.6b03517
摘要
Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Toward this goal, we have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug, in this case the small molecule anesthetic propofol, upon the application of focused ultrasound. These nanoparticles are composed of biodegradable and biocompatible constituents and are activated using sonication parameters that are readily achievable by current clinical transcranial focused ultrasound systems. These particles are potent enough that their activation can silence seizures in an acute rat seizure model. Notably, there is no evidence of brain parenchymal damage or blood-brain barrier opening with their use. Further development of these particles promises noninvasive, focal, and image-guided clinical neuromodulation along a variety of pharmacological axes.
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