Medical therapy refractory salt-sensitive hypertension: Liddle’s syndrome

• Various combinations of beta blocker, angiotensin—converting enzymes (ACE) inhibitors, thiazide diuretics, and sodium restricted diet, blood pressure is not controlled in patients wit Liddle's syndrome. • In a patient with hypertension refractory to appropriate medical treatment and hypokalemic alkalosis following medical conditions can be considered for differential diagnosis: primary aldosteronism, Cushing's syndrome, pheochromocytoma, renovascular hypertension, some forms of congenital adrenal hyperplasia, Liddle's syndrome and syndrome of mineralocorticoid excess. • Response to amiloride without any recurrence of hypertension and hypokalemia can be a confirmatory result to diagnose Liddle's syndrome.