光催化
试剂
铜
化学
催化作用
光化学
可见光谱
芳基
三氟甲基
组合化学
反应条件
有机化学
材料科学
光催化
光电子学
烷基
作者
Shengnan Yang,Miao Chen,Pingping Tang
标识
DOI:10.1002/anie.201901447
摘要
We report the development of photoredox-catalyzed and copper-promoted trifluoromethoxylation of arenediazonium tetrafluoroborates, with trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxylation reagent. This new method takes advantage of visible-light photoredox catalysis to generate the aryl radical under mild conditions, combined with copper-promoted selective trifluoromethoxylation. The reaction is scalable, tolerates a wide range of functional groups, and proceeds regioselectively under mild reaction conditions. Furthermore, mechanistic studies suggested that a Cs[Cu(OCF3 )2 ] intermediate might be generated during the reaction.
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