胶粘剂
材料科学
自愈水凝胶
生物医学工程
粘附
药物输送
绷带
生物相容性
四氟乙烯
聚合物
纳米技术
复合材料
高分子化学
共聚物
外科
图层(电子)
医学
冶金
作者
Jing Chen,Dong Wang,Long‐Hai Wang,Wanjun Liu,Alan Chiu,Kaavian Shariati,Qingsheng Liu,Xi Wang,Zhe Zhong,James Webb,Robert E. Schwartz,Nikolaos Bouklas,Minglin Ma
标识
DOI:10.1002/adma.202001628
摘要
Abstract Hydrogels with adhesive properties have potential for numerous biomedical applications. Here, the design of a novel, intrinsically adhesive hydrogel and its use in developing internal therapeutic bandages is reported. The design involves incorporation of “triple hydrogen bonding clusters” (THBCs) as side groups into the hydrogel matrix. The THBC through a unique “load sharing” effect and an increase in bond density results in strong adhesions of the hydrogel to a range of surfaces, including glass, plastic, wood, poly(tetrafluoroethylene) (PTFE), stainless steel, and biological tissues, even without any chemical reaction. Using the adhesive hydrogel, tissue‐adhesive bandages are developed for either targeted and sustained release of chemotherapeutic nanodrug for liver cancer treatment, or anchored delivery of pancreatic islets for a potential type 1 diabetes (T1D) cell replacement therapy. Stable adhesion of the bandage inside the body enables almost complete tumor suppression in an orthotopic liver cancer mouse model and ≈1 month diabetes correction in chemically induced diabetic mice.
科研通智能强力驱动
Strongly Powered by AbleSci AI