纤维化
炎症
藤黄蛋白C
促炎细胞因子
背景(考古学)
基质细胞蛋白
心肌炎
细胞外基质
医学
生物标志物
心肌梗塞
Tenascin公司
病理
心脏纤维化
再生(生物学)
免疫学
生物
心脏病学
细胞生物学
免疫组织化学
纤维连接蛋白
古生物学
生物化学
作者
Kyoko Imanaka‐Yoshida,Isao Tawara,Toshimichi Yoshida
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2020-11-01
卷期号:319 (5): C781-C796
被引量:46
标识
DOI:10.1152/ajpcell.00353.2020
摘要
Tenascin-C (TNC) is a large extracellular matrix glycoprotein classified as a matricellular protein that is generally upregulated at high levels during physiological and pathological tissue remodeling and is involved in important biological signaling pathways. In the heart, TNC is transiently expressed at several important steps during embryonic development and is sparsely detected in normal adult heart but is re-expressed in a spatiotemporally restricted manner under pathological conditions associated with inflammation, such as myocardial infarction, hypertensive cardiac fibrosis, myocarditis, dilated cardiomyopathy, and Kawasaki disease. Despite its characteristic and spatiotemporally restricted expression, TNC knockout mice develop a grossly normal phenotype. However, various disease models using TNC null mice combined with in vitro experiments have revealed many important functions for TNC and multiple molecular cascades that control cellular responses in inflammation, tissue repair, and even myocardial regeneration. TNC has context-dependent diverse functions and, thus, may exert both harmful and beneficial effects in damaged hearts. However, TNC appears to deteriorate adverse ventricular remodeling by proinflammatory and profibrotic effects in most cases. Its specific expression also makes TNC a feasible diagnostic biomarker and target for molecular imaging to assess inflammation in the heart. Several preclinical studies have shown the utility of TNC as a biomarker for assessing the prognosis of patients and selecting appropriate therapy, particularly for inflammatory heart diseases.
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