视网膜
神经科学
青光眼
生物
程序性细胞死亡
眼压
视网膜
再生(生物学)
细胞生物学
医学
眼科
细胞凋亡
生物化学
作者
Kevin A. Guttenplan,Benjamin K. Stafford,Rana N. El-Danaf,Drew Adler,Alexandra E. Münch,Maya K. Weigel,Andrew D. Huberman,Shane A. Liddelow
出处
期刊:Cell Reports
[Elsevier]
日期:2020-06-01
卷期号:31 (12): 107776-107776
被引量:135
标识
DOI:10.1016/j.celrep.2020.107776
摘要
Summary
Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells (RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We show that preventing the formation of neuroinflammatory reactive astrocytes prevents the death of RGCs normally seen in a mouse model of glaucoma. Furthermore, we show that these spared RGCs are electrophysiologically functional and thus still have potential value for the function and regeneration of the retina. Finally, we demonstrate that the death of RGCs depends on a combination of both an injury to the neurons and the presence of reactive astrocytes, suggesting a model that may explain why reactive astrocytes are toxic only in some circumstances. Altogether, these findings highlight reactive astrocytes as drivers of RGC death in a chronic neurodegenerative disease of the eye.
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