生物
肺纤维化
转化生长因子
信号转导
纤维化
细胞生物学
癌症研究
内科学
医学
作者
Xuemin Gao,Hong Xu,Danfeng Xu,Shumin Li,Zhongqiu Wei,Wenchen Cai,Na Mao,Fuyu Jin,Yaqian Li,Tian Li,Yu Xue,Heliang Liu,Yang Fang
标识
DOI:10.1016/j.yexcr.2020.111878
摘要
Occupational exposure to silica dust particles was the major cause of pulmonary fibrosis, and many miRNAs have been demonstrated to regulate target mRNAs in silicosis. In the present study, we found that a decreasing level of miR-411–3p in silicosis rats and lung fibroblasts induced by TGF-β1. Enlargement of miR-411–3p could inhibit the cell proliferation and migration in lung fibroblasts with TGF-β1 treatment and attenuate lung fibrosis in silicotic mice. In addition, a mechanistic study showed that miR-411–3p exert its inhibitory effect on Smad ubiquitination regulatory factor 2 (Smurf2) expression and decrease ubiquitination degradation of Smad7 regulated by smurf2, result in blocking of TGF-β/Smad signaling. We proposed that increased expression of miR-411–3p abrogates silicosis by blocking activation of TGF-β/Smad signaling through decreasing ubiquitination degradation effect of smurf2 on Smad7.
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