衰老
免疫系统
细胞生物学
生物
表型
重编程
细胞衰老
分泌物
电池类型
细胞代谢
细胞
新陈代谢
免疫学
遗传学
生物化学
基因
作者
Daniela Frasca,Yara Bou Saada,Denisse Garcia,Bertrand Friguet
标识
DOI:10.1016/j.mad.2020.111428
摘要
Many cellular stresses induce cellular senescence and the irreversible arrest of cell proliferation in different cell types. Although blocked in their capacity to divide, senescent cells are metabolically active and are characterized by a different metabolic phenotype as compared to non-senescent cells. Changes observed in senescent cells depend from the cell type and lead to an adaptative flexibility in the type of metabolism. This metabolic reprogramming is needed to cope with survival and with the energetic demands of the senescent program that include the increased secretion of senescence-associated secretory phenotype factors.
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