纳米医学
纳米器件
商业化
纳米技术
药物输送
纳米团簇
纳米颗粒
材料科学
业务
营销
作者
Rishi Paliwal,R. Jayachandra Babu,Srinath Palakurthi
出处
期刊:Aaps Pharmscitech
[Springer Nature]
日期:2014-07-22
卷期号:15 (6): 1527-1534
被引量:215
标识
DOI:10.1208/s12249-014-0177-9
摘要
Nanomedicine refers to biomedical and pharmaceutical applications of nanosized cargos of drugs/vaccine/DNA therapeutics including nanoparticles, nanoclusters, and nanospheres. Such particles have unique characteristics related to their size, surface, drug loading, and targeting potential. They are widely used to combat disease by controlled delivery of bioactive(s) or for diagnosis of life-threatening problems in their very early stage. The bioactive agent can be combined with a diagnostic agent in a nanodevice for theragnostic applications. However, the formulation scientist faces numerous challenges related to their development, scale-up feasibilities, regulatory aspects, and commercialization. This article reviews recent progress in the method of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization.
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