Synthesis and Antibacterial Activity of New (2,3-dioxo-indolin-1-yl) acetamides

The synthesis of a novel series of isatin derivatives bearing an acetamide group is described. These 2-(2,3- dioxo-indolin-1-yl)acetamide derivatives were synthesized by N-carboxymethylation of isatin followed by conversion of the carboxylic acid function into a tertiary amide. In a preliminary study, this series of compounds were tested in vitro for their biological activity, against various strains of bacteria. Keywords: Isatin, acetamide, tertiary amide, in vitro biological activity