化学
二乙胺
三苯基膦
产量(工程)
药物化学
甲苯
吡啶
氢氧化钠
铜
碘甲烷
钯
氯化物
碘化物
甲烷氧化偶联
高分子化学
有机化学
催化作用
材料科学
冶金
作者
Leopoldo Delia Ciana,Albert Haim
标识
DOI:10.1002/jhet.5570210268
摘要
Abstract 2‐Methyl‐4‐(4‐pyridyl)‐3‐butyn‐2‐ol ( 2 ) was prepared in 70% yield by the reaction of 4‐bromopyridine with 2‐methyl‐3‐butyn‐2‐ol in diethylamine in the presence of bis(triphenylphosphine)palladium(II) chloride and copper(I) iodide. Removal of the protective group in 2 by refluxing with sodium hydroxide in toluene yields (90%) 4‐ethynylpyridine ( 3 ). Oxidative coupling of 3 in pyridine by dioxygen in the presence of copper(I) chloride produces a 92% yield of 1,4‐bis(4‐pyridyl)butadiyne.
科研通智能强力驱动
Strongly Powered by AbleSci AI