甘露糖受体
受体
内吞循环
内体
糖蛋白
甘露糖
跨膜蛋白
细胞生物学
跨膜结构域
生物
细胞表面受体
C型凝集素
凝集素
细胞质
生物化学
化学
内吞作用
体外
巨噬细胞
标识
DOI:10.1016/s0304-4165(02)00319-7
摘要
The mannose receptor family comprises four glycoproteins each of which is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single fibronectin type II (FNII) domain and eight to ten C-type lectin-like domains (CTLDs). Characteristically, these proteins are able to recycle between the plasma membrane and the endosomal apparatus due to discrete motifs present within their cytoplasmic domains. This review discusses the structure and function of these four proteins-the mannose receptor (MR), the M-type receptor for secretory phospholipases A(2) (PLA(2)R), DEC-205/gp200-MR6 and Endo180/uPARAP. Despite their overall structural similarity, these four receptors have evolved to use different domains to interact with discrete ligands. In addition, they differ in their ability to mediate endocytic and phagocytic events and in their intracellular destinations. Together, they represent a unique group of multidomain, multifunctional receptors.
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