染色质
生物
DNA
DNA损伤
细胞生物学
DNA修复
计算生物学
遗传学
作者
Stephanie Jungmichel,Manuel Stucki
出处
期刊:Chromosoma
[Springer Nature]
日期:2010-03-12
卷期号:119 (4): 337-349
被引量:84
标识
DOI:10.1007/s00412-010-0266-9
摘要
The chromatin structure is important for recognition and repair of DNA damage. Many DNA damage response proteins accumulate in large chromatin domains flanking sites of DNA double-strand breaks. The assembly of these structures—usually termed DNA damage foci—is primarily regulated by MDC1, a large nuclear mediator/adaptor protein that is composed of several distinct structural and functional domains. Here, we are summarizing the latest discoveries about the mechanisms by which MDC1 mediates DNA damage foci formation, and we are reviewing the considerable efforts taken to understand the functional implication of these structures.
科研通智能强力驱动
Strongly Powered by AbleSci AI