动脉硬化
医学
C反应蛋白
内科学
心脏病学
动脉硬化
逻辑回归
多元分析
血压
炎症
作者
Jung-Yoon Yang,Ji-Sook Nam,Hee‐Jeong Choi
标识
DOI:10.1016/j.cca.2012.06.004
摘要
The detection of preclinical arterial dysfunction may improve the ability to predict the subsequent risk of its outcomes and lead to optimal strategies to prevent overt vascular damage. The aim of this study was to investigate whether high high-sensitivity C-reactive protein (hsCRP) is associated with increased arterial stiffness in Korean adults.The association between the hsCRP and cardiac-ankle vascular index (CAVI) was evaluated in 1347 healthy adults. Multivariate logistic analyses were done to identify the association of the hsCRP levels and high CAVI (≥ 8.0).The age and gender adjusted mean values of the CAVI were significantly higher in the intermediate and high hsCRP groups than in the low hsCRP group. For all the study subjects, an intermediate and high hsCRP was associated with a high CAVI after adjusting for covariates. However, this association was observed only in female subjects in gender-specific analyses and did not change after further adjustment for other variables.Even within the normal range, a high hsCRP level was a predictor of high CAVI in healthy adult females. This finding suggests that the risk of arteriosclerosis may be high in females whose hsCRP level is > 0.1mg/dl even in low-risk females.
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