慢性荨麻疹
白细胞介素18
免疫学
医学
白细胞介素33
炎症
白细胞介素
受体
内科学
细胞因子
作者
Ilaria Puxeddu,Paola Italiani,Paola Grazioli,Federico Pratesi,Filomena Panza,Debora Bartaloni,Valeria Rocchi,Isabella Del Corso,Diana Boraschi,Paola Migliorini
出处
期刊:Cytokine
[Elsevier]
日期:2013-03-01
卷期号:61 (3): 741-743
被引量:47
标识
DOI:10.1016/j.cyto.2013.01.015
摘要
Overproduction of IL-18 has been described in chronic urticaria. To evaluate free IL-18 and IL-33 in chronic spontaneous urticaria (CSU). IL-18, its inhibitor IL-18BP, IL-33 and its soluble receptor ST2 (sST2) were measured (ELISA) in the sera of 73 CSU patients. Free IL-18 was calculated (law of mass action). Autologous serum skin test (ASST) was performed in all patients. Total IL-18, IL-18BP and free IL-18 serum levels were significantly higher in CSU than in controls. IL-18 and IL-18BP increased significantly in both ASST-positive and negative subgroups. Free IL-18 resulted significantly higher in the ASST-negative, but not in the ASST-positive subgroup. No differences in IL-33/sST2 levels were detected between CSU and controls. Increased levels of free IL-18 and IL-18BP, but not IL-33, was detected in CSU. Whether IL-18 up-regulation is a consequence of inflammation or one of the causes of the pathology needs to be addressed.
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