Homogenous Iron-Catalysed Deuteration of Electron-Rich Arenes and Heteroarenes

Abstract Deuterated organic molecules are of interest for many applications ranging from mechanistic investigations in basic organic and physical chemistry to the development of new pharmaceuticals. Thus, methodologies for isotope-labelling reactions continue to be important. Here, a convenient methodology for hydrogen/deuterium exchange reactions in electron-rich arenes is reported using simple iron salts and deuterium oxide as isotope source.